Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM4B | O94953 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782190 | 0.83 | PKM (0.48) | ALDH1A1HDAC1HDAC2CCNCCDK8 | |
| SCHEMBL18171881 | 0.79 | PDGFRB (0.61) | HTTSMN1; SMN2LMNAALDH1A1CCNC | |
| SCHEMBL782077 | 0.78 | KCNH2 (0.43) | HTTSMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL18171879 | 0.76 | LMNA (0.49) | HTTSMN1; SMN2LMNAALDH1A1PDE10A | |
| SCHEMBL18614405 | 0.72 | PIK3CA (0.47) | HTTLMNAHDAC1HDAC2MAPT | |
| SCHEMBL13226945 | 0.72 | PABPC1 (0.41) | HTTALDH1A1CCNCCDK8MAPT | |
| SCHEMBL780199 | 0.72 | PABPC1 (0.44) | HTTMAPTPDE10A | |
| SCHEMBL28357678 | 0.69 | MEN1 (0.58) | LMNAMAPT | |
| SCHEMBL7994379 | 0.69 | PABPC1 (0.38) | HTTALDH1A1CCNCCDK8MAPT | |
| SCHEMBL18171874 | 0.69 | HDAC8 (0.38) | HTTSMN1; SMN2LMNAALDH1A1CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016170163-A1 | SUBSTITUTED QUINOXALINES AND BENZOTRIAZINE P70S6 KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2016-10-27 | — | — | WO | disclosed |