Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782036 | 0.87 | PIK3CA (0.43) | SMN1; SMN2LMNAPIK3CDPIK3R1HTT | |
| SCHEMBL780459 | 0.84 | MAOB (0.49) | SMN1; SMN2LMNAPIK3CDPIK3R1HTT | |
| SCHEMBL782078 | 0.80 | AGXT (0.42) | SMN1; SMN2LMNAPIK3CDPIK3R1HTT | |
| SCHEMBL780097 | 0.80 | PIK3CA (0.48) | SMN1; SMN2KMT2AMAPTTSHRERAP1 | |
| SCHEMBL781082 | 0.80 | PIK3CA (0.48) | SMN1; SMN2LMNAPIK3CDPIK3R1HTT | |
| SCHEMBL780100 | 0.77 | PIK3CA (0.46) | SMN1; SMN2KMT2AMAPTTSHRPIK3CA | |
| SCHEMBL782822 | 0.76 | PIK3CA (0.45) | SMN1; SMN2LMNAPIK3CDPIK3R1HTT | |
| Hydrochloric Acid SCHEMBL781422 | 0.76 | PIK3CA (0.45) | SMN1; SMN2KMT2AMAPTTSHRPIK3CA | |
| SCHEMBL18171877 | 0.76 | DGAT1 (0.43) | SMN1; SMN2LMNAPIK3CDPIK3R1HTT | |
| SCHEMBL21842701 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPIK3CDPIK3R1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016170163-A1 | SUBSTITUTED QUINOXALINES AND BENZOTRIAZINE P70S6 KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2016-10-27 | — | — | WO | disclosed |