Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.50 |
| ▸ | GGT1 | P19440 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14771649 | 1.00 | HSD17B10 (0.52) | HSD17B10KDM4ECYP2C9LMNACYP1A2 | |
| SCHEMBL14771613 | 0.82 | ALDH1A1 (0.47) | HSD17B10KDM4ECYP2C9LMNAHPGD | |
| SCHEMBL14771609 | 0.82 | ALDH1A1 (0.47) | HSD17B10KDM4ECYP2C9LMNAHPGD | |
| SCHEMBL14771671 | 0.81 | SMN1; SMN2 (0.45) | HSD17B10KDM4ECYP2C9LMNAHPGD | |
| SCHEMBL14771596 | 0.81 | LMNA (0.50) | HSD17B10KDM4ECYP2C9LMNAHPGD | |
| SCHEMBL668289 | 0.81 | LMNA (0.50) | HSD17B10KDM4ECYP2C9LMNAHPGD | |
| SCHEMBL14771678 | 0.81 | SMN1; SMN2 (0.45) | HSD17B10KDM4ECYP2C9LMNAHPGD | |
| SCHEMBL4650189 | 0.80 | ALDH1A1 (0.51) | HSD17B10KDM4ECYP2C9LMNAHPGD | |
| SCHEMBL14771667 | 0.80 | ALDH1A1 (0.51) | HSD17B10KDM4ECYP2C9LMNAHPGD | |
| SCHEMBL14771663 | 0.80 | ALDH1A1 (0.51) | HSD17B10KDM4ECYP2C9LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3346991-A1 | PROTECTING ORAL OVERDOSE WITH ABUSE DETERRENT IMMEDIATE RELEASE FORMULATIONS | Grünenthal GmbH (DE) | 2018-07-18 | — | — | EP | disclosed |
| EP-3285747-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES | Grünenthal GmbH (DE) | 2018-02-28 | — | — | EP | disclosed |
| EP-3285748-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM DIFFERENT PARTICLES | Grünenthal GmbH (DE) | 2018-02-28 | — | — | EP | disclosed |
| EP-3285746-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A POWDER | Grünenthal GmbH (DE) | 2018-02-28 | — | — | EP | disclosed |
| WO-2017042325-A1 | PROTECTING ORAL OVERDOSE WITH ABUSE DETERRENT IMMEDIATE RELEASE FORMULATIONS | Grünenthal GmbH (DE) | 2017-03-16 | — | — | WO | disclosed |
| WO-2016170095-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A POWDER | Grünenthal GmbH (DE) | 2016-10-27 | — | — | WO | disclosed |
| WO-2016170094-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES | Grünenthal GmbH (DE) | 2016-10-27 | — | — | WO | disclosed |
| WO-2016170096-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM DIFFERENT PARTICLES | Grünenthal GmbH (DE) | 2016-10-27 | — | — | WO | disclosed |