SCHEMBL1817200

SCHEMBL1817200

Clc1ccc(C2=NCCO2)cc1

nearest known ligand 0.54

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LSS P48449 1/20 0.51
KCNH2 Q12809 1/20 0.43
HRH3 Q9Y5N1 1/20 0.43
LTA4H P09960 1/20 0.42
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.40
RECQL P46063 1/20 0.40
NOTUM Q6P988 1/20 0.39
MAOB P27338 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Perchlorate SCHEMBL10962989 0.89 LSS (0.48) LSSKCNH2HRH3LTA4HKDM4E
SCHEMBL132013 0.89 KCNH2 (0.49) LSSKCNH2HRH3LTA4H
SCHEMBL10520360 0.81 KCNH2 (0.48) LSSKCNH2HRH3LTA4H
SCHEMBL20410837 0.81 KCNH2 (0.44) LSSKCNH2HRH3LTA4H
SCHEMBL9475161 0.81 KCNH2 (0.44) LSSKCNH2HRH3LTA4H
SCHEMBL961792 0.79 KCNN4 (0.44) KCNH2HRH3LTA4HALDH1A1
SCHEMBL1856955 0.79 NPC1 (0.43) LSSKCNH2HRH3LTA4HKDM4E
SCHEMBL17677999 0.79 KCNH2 (0.43) LSSKCNH2HRH3LTA4H
SCHEMBL5464687 0.79 NPC1 (0.43) LSSKCNH2HRH3LTA4HNOTUM
SCHEMBL20410952 0.79 KCNH2 (0.43) LSSKCNH2HRH3LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108987-B N-substituted indenoisoquinolinone derivative and preparation method thereof 华侨大学 2023-05-26 CN claimed
CN-115108987-A N-substituted indenoisoquinolinone derivative and preparation method thereof 华侨大学 2022-09-27 CN claimed
EP-1611120-A4 NOVEL METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASES CORTICAL PTY LTD (AU) 2008-04-23 EP claimed
US-20070010563-A1 Novel methods for the treatment of inflammatory diseases CORTICAL PTY LTD (AU) 2007-01-11 US claimed
EP-1611120-A1 NOVEL METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASES Cortical Pty Ltd (AU) 2006-01-04 EP claimed
WO-2004089927-A1 NOVEL METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASES CORTICAL PTY LTD (AU) 2004-10-21 WO claimed
CN-115108987-B N-substituted indenoisoquinolinone derivative and preparation method thereof 华侨大学 2023-05-26 CN disclosed
CN-115108987-A N-substituted indenoisoquinolinone derivative and preparation method thereof 华侨大学 2022-09-27 CN disclosed
CN-113999131-B Method for preparing amide derivative by amination of alkyl C-H bond under catalysis of nickel promoted by visible light 苏州大学 2022-06-28 CN disclosed
CN-113999131-A Method for preparing amide derivative by amination of alkyl C-H bond under catalysis of nickel promoted by visible light 苏州大学 2022-02-01 CN disclosed
CN-107721874-B Method for preparing nitrate compounds by adopting micro-flow field reaction technology 南京工业大学 2020-05-19 CN disclosed
US-20150000824-A1 ADHESIVE SHEET FOR PROTECTING BACK FACE OF SOLAR BATTERY MODULE, AND SOLAR BATTERY MODULE USING THE SAME KEIWA INC. (JP) 2015-01-01 US disclosed
CN-102051138-B Adhesive sheet for protecting back face of solar battery module, and solar battery module using the same KEIWA INC 2014-09-03 CN disclosed
US-6258512-B1 PHOTOSENSITIVE LAYER CONTAINING TITANIUM OXIDE GRAINS AND BLEND CONTAINING ORGANOMETALLIC POLYMER FUJI PHOTO FILM CO., LTD. (JP) 2001-07-10 US disclosed
US-6194599-B1 Process for preparing biaryl compounds CATALYTICA, INC. 2001-02-27 US disclosed
US-6183923-B1 CAPABLE OF PROVIDING PRINTING PLATE WHICH ENABLES TO PRINT GREAT NUMBER OF PRINTED MATTER HAVING CLEAR IMAGES FREE FROM BACKGROUND STAINS FUJI PHOTO FILM CO., LTD. (JP) 2001-02-06 US disclosed
US-5922898-A Process for preparing biaryl compounds CATALYTICA PHARMACEUTICALS, INC. (US) 1999-07-13 US disclosed
EP-0507790-A1 PROCESS FOR PREPARING CROSSLINKED POLYMERS Henkel Kommanditgesellschaft auf Aktien (DE) 1992-10-14 EP disclosed
WO-1991009897-A2 PROCESS FOR PREPARING CROSSLINKED POLYMERS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1991-07-11 WO disclosed
US-4467115-A Method for preparing branched polyethylenimine INSTITUT NEFTEKHIMICHESKOGO SINTEZA IMENI A.V. TONCHEVA AKADEMII NAUK SSSR (SU) 1984-08-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070010563-A1 Novel methods for the treatment of inflammatory diseases MIF, CCL2, CCL11 LSS 1638/4885KCNH2 4804/4885HRH3 1206/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.