Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25028822 | 0.80 | KMT2A (0.40) | KMT2ALMNAKDM4EPDE2AMAPK1 | |
| SCHEMBL27466228 | 0.77 | KMT2A (0.54) | KMT2ALMNAKDM4EABL1PTGS1 | |
| SCHEMBL18172158 | 0.77 | S1PR3 (0.43) | — | |
| SCHEMBL22758118 | 0.76 | KMT2A (0.53) | KMT2ALMNAKDM4EABL1PTGS1 | |
| SCHEMBL18172003 | 0.74 | ALDH1A1 (0.41) | KMT2ALMNAKDM4EMAPK1ALDH1A1 | |
| SCHEMBL22499955 | 0.71 | KMT2A (0.50) | KMT2ALMNAKDM4EABL1PTGS1 | |
| SCHEMBL18172071 | 0.71 | PDE2A (0.49) | KDM4EPDE2ASCN9AALDH1A1GAA | |
| SCHEMBL28999785 | 0.71 | KMT2A (0.50) | KMT2ALMNAKDM4EABL1PTGS1 | |
| SCHEMBL3206362 | 0.71 | ALDH1A1 (0.46) | KMT2AKDM4EPTGS1PDE2ASCN9A | |
| SCHEMBL26925870 | 0.70 | KMT2A (0.47) | KMT2ALMNAKDM4EABL1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286178-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | Almirall S.A. (ES) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016170009-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | ALMIRALL, S.A. (ES) | 2016-10-27 | — | — | WO | disclosed |