Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL469147 | 0.82 | CARM1 (0.47) | HRH1KCNH2ALDH1A1SIGMAR1 | |
| SCHEMBL663338 | 0.82 | ALDH1A1 (0.34) | GNAI3GNAO1GNAI1ALDH1A1MAPK1 | |
| SCHEMBL441449 | 0.79 | HRH1 (0.34) | HRH1KCNH2ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL7884661 | 0.79 | KCNH2 (0.34) | HRH1KCNH2GNAO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL13437776 | 0.77 | SMN1; SMN2 (0.43) | HRH1KCNH2GNAI3GNAO1GNAI1 | |
| SCHEMBL13437773 | 0.77 | SMN1; SMN2 (0.43) | KCNH2GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL8967602 | 0.75 | SMN1; SMN2 (0.43) | ALDH1A1SMN1; SMN2MAPK1ALOX15SIGMAR1 | |
| SCHEMBL18803169 | 0.75 | PAOX (0.38) | SMN1; SMN2SIGMAR1 | |
| SCHEMBL13437772 | 0.75 | SMN1; SMN2 (0.36) | HRH1KCNH2SMN1; SMN2ALOX15 | |
| SCHEMBL8324635 | 0.74 | DRD2 (0.47) | GNAI3GNAO1GNAI1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286172-B1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2019-06-12 | — | — | EP | claimed |
| US-20180290976-A1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. | 2018-10-11 | — | — | US | claimed |
| EP-3286172-A1 | LSD1 INHIBITORS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2018-02-28 | — | — | EP | claimed |
| WO-2016172496-A1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2016-10-27 | — | — | WO | claimed |
| EP-3286172-B1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2019-06-12 | — | — | EP | disclosed |
| US-20180290976-A1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. | 2018-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180290976-A1 | LSD1 INHIBITORS AND USES THEREOF | KDM1B, KDM1A, KDM2A | HRH1 1255/4885KCNH2 3023/4885GNAI3 2539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.