Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | CTH | P32929 | 1/20 | 0.36 |
| ▸ | CBS | P35520 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7262941 | 1.00 | HSD17B10 (0.38) | HSD17B10BLMPMP22TSHRCTH | |
| SCHEMBL3729335 | 1.00 | HSD17B10 (0.38) | HSD17B10BLMPMP22TSHRCTH | |
| SCHEMBL1438928 | 0.95 | — | — | |
| Hydrochloric Acid SCHEMBL4912304 | 0.92 | — | — | |
| SCHEMBL81956 | 0.87 | HSD17B10 (0.46) | HSD17B10BLMPMP22TSHRCTH | |
| SCHEMBL6666413 | 0.87 | HSD17B10 (0.46) | HSD17B10BLMPMP22TSHRCTH | |
| SCHEMBL14950228 | 0.87 | HSD17B10 (0.46) | HSD17B10BLMPMP22TSHRCTH | |
| SCHEMBL6664456 | 0.87 | HSD17B10 (0.46) | HSD17B10BLMPMP22TSHRCTH | |
| SCHEMBL20534906 | 0.87 | HSD17B10 (0.46) | HSD17B10BLMPMP22TSHRCTH | |
| SCHEMBL25495618 | 0.87 | HSD17B10 (0.46) | HSD17B10BLMPMP22TSHRCTH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3285810-A1 | IAP E3 LIGASE DIRECTED PROTEOLYSIS TARGETING CHIMERIC MOLECULES | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016169989-A1 | IAP E3 LIGASE DIRECTED PROTEOLYSIS TARGETING CHIMERIC MOLECULES | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-10-27 | — | — | WO | disclosed |