Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5995052 | 0.75 | ALDH1A1 (0.65) | MITFALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL22187033 | 0.73 | CHRM2 (0.37) | MITFALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL22074331 | 0.72 | TRPM8 (0.67) | ALDH1A1SMN1; SMN2NPC1RAB9ATRPM8 | |
| SCHEMBL19064490 | 0.70 | SLC6A2 (0.34) | MITFALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL20777249 | 0.68 | TRPM8 (0.57) | ALDH1A1SMN1; SMN2KDM4ELMNATRPM8 | |
| SCHEMBL20772875 | 0.68 | TRPM8 (0.52) | ALDH1A1SMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL30579664 | 0.68 | TRPM8 (0.57) | ALDH1A1SMN1; SMN2KDM4ELMNATRPM8 | |
| SCHEMBL20773064 | 0.67 | NOTUM (0.46) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL20772769 | 0.67 | TRPM8 (0.53) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL20772799 | 0.67 | TRPM8 (0.52) | ALDH1A1KDM4EOPRD1TRPM8POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286183-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | Cellcentric Ltd (GB) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016170324-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | CELLCENTRIC LTD (GB) | 2016-10-27 | — | — | WO | disclosed |