SCHEMBL18174750

SCHEMBL18174750

Cc1cnccc1-c1ccc(-c2c3ccccc3c(-c3cccc(-c4ccncc4C)c3)c3ccccc23)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 1/20 0.43
CYP17A1 P05093 5/20 0.42
CYP1A2 P05177 4/20 0.42
S1PR1 P21453 2/20 0.40
S1PR3 Q99500 1/20 0.40
TNF P01375 1/20 0.40
CYP19A1 P11511 1/20 0.39
HAVCR2 Q8TDQ0 1/20 0.39
RPS6KA3 P51812 2/20 0.38
CHEK1 O14757 1/20 0.38
RPS6KA5 O75582 1/20 0.38
MAP4K4 O95819 1/20 0.38
PRKCG P05129 1/20 0.38
CDK1 P06493 1/20 0.38
PRKACA P17612 1/20 0.38
RPS6KB1 P23443 1/20 0.38
CDK2 P24941 1/20 0.38
MAPK1 P28482 1/20 0.38
AKT1 P31749 1/20 0.38
AKT2 P31751 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15161102 0.95 GRM4 (0.46) GRM4CYP17A1CYP1A2S1PR1S1PR3
SCHEMBL18174730 0.95 CYP17A1 (0.47) GRM4CYP17A1CYP1A2DHODHABL1
SCHEMBL15161084 0.95 CYP17A1 (0.47) GRM4CYP17A1CYP1A2DHODHABL1
SCHEMBL18174753 0.93 PIK3CA (0.45) GRM4CYP17A1CYP1A2S1PR1S1PR3
SCHEMBL18174716 0.92 PIK3CA (0.47) GRM4CYP17A1CYP1A2CYP19A1RPS6KA3
SCHEMBL18174564 0.91 GRM4 (0.49) GRM4CYP17A1CYP1A2S1PR1S1PR3
SCHEMBL9613162 0.90 TNF (0.43) GRM4CYP17A1CYP1A2S1PR1S1PR3
SCHEMBL18174755 0.90 DHODH (0.41) GRM4CYP17A1CYP1A2S1PR1S1PR3
SCHEMBL10032186 0.89 CYP11B1 (0.47) CYP17A1CYP1A2CYP19A1CCNCCDK8
SCHEMBL15160978 0.89 GRM4 (0.42) GRM4CYP17A1CYP1A2S1PR1S1PR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9478750-B2 Anthracene derivative and organic electroluminescent element using the same JNC CORPORATION (JP) 2016-10-25 US disclosed
US-9478750-B2 Anthracene derivative and organic electroluminescent element using the same JNC CORPORATION (JP) 2016-10-25 US disclosed