Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.53 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1814831 | 0.87 | EGLN1 (0.69) | EGLN1BBOX1FTOTHRATHRB | |
| SCHEMBL12896210 | 0.84 | EGLN1 (0.77) | EGLN1BBOX1FTOALDH1A1LMNA | |
| SCHEMBL12896201 | 0.81 | EGLN1 (0.57) | EGLN1CASP1BBOX1FTOALDH1A1 | |
| SCHEMBL1817092 | 0.79 | EGLN1 (0.43) | EGLN1ALDH1A1KDM4ESMN1; SMN2PKM | |
| SCHEMBL12896206 | 0.79 | EGLN1 (0.56) | EGLN1CASP1BBOX1FTOALDH1A1 | |
| SCHEMBL12896207 | 0.78 | EGLN1 (0.54) | EGLN1CASP1BBOX1FTOALDH1A1 | |
| SCHEMBL1816427 | 0.76 | EGLN1 (0.46) | EGLN1BBOX1FTOLMNAKDM4E | |
| SCHEMBL1820872 | 0.76 | EGLN1 (0.44) | EGLN1 | |
| SCHEMBL1816987 | 0.76 | EGLN1 (0.57) | EGLN1BBOX1FTO | |
| SCHEMBL1816993 | 0.76 | EGLN1 (0.57) | EGLN1BBOX1FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056725-A1 | PYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | CRYSTALGENOMICS, INC. (KR) | 2011-05-12 | — | — | WO | disclosed |