SCHEMBL1820872

SCHEMBL1820872

O=C(Cl)c1nc(Cl)c2c(sc3c(Cl)nccc32)c1O

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 3/20 0.44
HIPK2 Q9H2X6 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1816427 0.89 EGLN1 (0.46) EGLN1HIPK2
SCHEMBL1817092 0.84 EGLN1 (0.43) EGLN1
SCHEMBL1814831 0.81 EGLN1 (0.69) EGLN1
SCHEMBL1816993 0.79 EGLN1 (0.57) EGLN1
SCHEMBL1816987 0.79 EGLN1 (0.57) EGLN1
SCHEMBL1817497 0.76 EGLN1 (0.53) EGLN1
SCHEMBL1807741 0.66 EGLN1 (0.46) EGLN1
SCHEMBL1808866 0.64 EGLN1 (0.71) EGLN1
SCHEMBL1811763 0.64 EGLN1 (0.43) EGLN1
SCHEMBL30959617 0.63 CHRM4 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011056725-A1 PYRIDINE DERIVATIVES AND METHODS OF USE THEREOF CRYSTALGENOMICS, INC. (KR) 2011-05-12 WO disclosed