Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1816427 | 0.84 | EGLN1 (0.46) | EGLN1KDM4ESMN1; SMN2RNASEH1 | |
| SCHEMBL1820872 | 0.84 | EGLN1 (0.44) | EGLN1 | |
| SCHEMBL1810341 | 0.82 | EGLN1 (0.40) | EGLN1KDM4EPKMALDH1A1SMN1; SMN2 | |
| SCHEMBL1807741 | 0.82 | EGLN1 (0.46) | EGLN1KDM4ESMN1; SMN2L3MBTL1ERCC1 | |
| SCHEMBL1814831 | 0.80 | EGLN1 (0.69) | EGLN1 | |
| SCHEMBL1816987 | 0.79 | EGLN1 (0.57) | EGLN1 | |
| SCHEMBL1816993 | 0.79 | EGLN1 (0.57) | EGLN1 | |
| SCHEMBL1817497 | 0.79 | EGLN1 (0.53) | EGLN1KDM4EPKMALDH1A1SMN1; SMN2 | |
| SCHEMBL1810830 | 0.77 | EGLN1 (0.46) | EGLN1KDM4EPKMALDH1A1SMN1; SMN2 | |
| SCHEMBL1811763 | 0.77 | EGLN1 (0.43) | EGLN1KDM4EPKMALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056725-A1 | PYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | CRYSTALGENOMICS, INC. (KR) | 2011-05-12 | — | — | WO | disclosed |