Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10039865 | 0.76 | PIK3CD (0.30) | ADORA2BADORA2A | |
| SCHEMBL19472283 | 0.69 | ADORA2B (0.41) | ADORA2BPDE4AADORA2APDE4BPDE4C | |
| SCHEMBL1539119 | 0.63 | ADORA2B (0.42) | ADORA2BPDE4AADORA2APDE4BPDE4C | |
| SCHEMBL19677248 | 0.62 | PDE4A (0.39) | ADORA2BPDE4AADORA2APDE4BPDE4C | |
| SCHEMBL19090548 | 0.61 | BRD4 (0.39) | ADORA2BPDE4AADORA2APDE4BPDE4C | |
| SCHEMBL14505648 | 0.60 | ADORA2B (0.47) | ADORA2BPDE4AADORA2APDE4BPDE4C | |
| SCHEMBL316279 | 0.60 | ADORA2B (1.00) | ADORA2BPDE4AADORA2APDE4BPDE4C | |
| SCHEMBL28973357 | 0.60 | LMNA (0.65) | ADORA2BPDE4AADORA2APDE4BPDE4C | |
| SCHEMBL30874782 | 0.58 | SMN1; SMN2 (0.55) | KMT2AALDH1A1GAAKDM4EHPGD | |
| SCHEMBL17210366 | 0.58 | MEN1 (0.33) | ADORA2BPDE4AADORA2APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2170309-B1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | HYDRA BIOSCIENCES INC (US) | 2016-10-26 | — | — | EP | disclosed |