Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15631561 | 0.75 | KIF11 (0.41) | KIF11SYKMKNK1PDE3BPDE3A | |
| SCHEMBL15631562 | 0.70 | SYK (0.38) | KIF11SYKMKNK1PDE3BPDE3A | |
| SCHEMBL10338441 | 0.70 | PDE3B (0.60) | KIF11SYKMKNK1PDE3BPDE3A | |
| SCHEMBL15631642 | 0.70 | MAPT (0.39) | KIF11SYKMKNK1PDE3BPDE3A | |
| SCHEMBL15631589 | 0.69 | MKNK1 (0.39) | KIF11SYKMKNK1P2RX3TP53 | |
| SCHEMBL15631569 | 0.69 | SYK (0.37) | KIF11SYKMKNK1PDE3BPDE3A | |
| SCHEMBL15631580 | 0.65 | IRAK4 (0.39) | KIF11SYKMKNK1P2RX3MAPT | |
| SCHEMBL15631556 | 0.65 | MAPT (0.41) | KIF11SYKMKNK1PDE3BPDE3A | |
| SCHEMBL12361999 | 0.65 | PDE3B (0.54) | KIF11SYKMKNK1PDE3BPDE3A | |
| SCHEMBL15631613 | 0.64 | SYK (0.43) | KIF11SYKMKNK1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897957-B1 | SUBSTITUTED PYRROLOPYRIMIDINYLAMINO-BENZOTHIAZOLONES AS MKNK KINASE INHIBITORS | Bayer Pharma AG (DE) | 2016-10-26 | — | — | EP | disclosed |