Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20032411 | 0.87 | HDAC8 (0.54) | HDAC8HDAC6ROCK2SLC7A5ALDH1A1 | |
| SCHEMBL18599247 | 0.84 | TERT (0.44) | GPR139ALDH1A1KMT2AADORA1GAA | |
| SCHEMBL9921712 | 0.83 | HDAC8 (0.47) | HDAC8HDAC6ROCK2SLC7A5BRD4 | |
| SCHEMBL19592283 | 0.83 | HDAC8 (0.42) | HDAC8HDAC6ROCK2SLC7A5BRD4 | |
| SCHEMBL171769 | 0.81 | HDAC8 (0.45) | HDAC8HDAC6ROCK2SLC7A5BRD4 | |
| SCHEMBL19592282 | 0.81 | HDAC8 (0.45) | HDAC8HDAC6ROCK2SLC7A5BRD4 | |
| SCHEMBL5947695 | 0.77 | BRD4 (0.44) | HDAC8HDAC6ROCK2SLC7A5BRD4 | |
| SCHEMBL14108019 | 0.77 | HDAC8 (0.53) | HDAC8HDAC6ROCK2SLC7A5ALDH1A1 | |
| SCHEMBL11928120 | 0.76 | HDAC8 (0.51) | HDAC8HDAC6ROCK2SLC7A5GPR139 | |
| SCHEMBL14983606 | 0.74 | HDAC8 (0.50) | HDAC8HDAC6ROCK2SLC7A5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343298-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-2474545-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2016-11-09 | — | — | EP | disclosed |
| EP-2455382-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2016-10-26 | — | — | EP | disclosed |