Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19062131 | 0.85 | TERT (0.49) | TERTSMN1; SMN2TP53BP1L3MBTL1KDM4E | |
| SCHEMBL12303198 | 0.85 | TERT (0.49) | TERTSMN1; SMN2TP53BP1L3MBTL1KDM4E | |
| SCHEMBL19592389 | 0.85 | TP53BP1 (0.43) | TERTSMN1; SMN2TP53BP1L3MBTL1KDM4E | |
| SCHEMBL18175876 | 0.84 | HDAC8 (0.45) | TP53BP1GPR139ALDH1A1KMT2AGAA | |
| SCHEMBL8737487 | 0.83 | TP53BP1 (0.46) | TERTSMN1; SMN2TP53BP1L3MBTL1KDM4E | |
| SCHEMBL19592388 | 0.82 | TERT (0.43) | TERTSMN1; SMN2TP53BP1L3MBTL1KDM4E | |
| SCHEMBL12829992 | 0.78 | L3MBTL1 (0.63) | SMN1; SMN2TP53BP1L3MBTL1KDM4EEPHX2 | |
| SCHEMBL11994348 | 0.78 | TP53BP1 (0.65) | TERTSMN1; SMN2TP53BP1L3MBTL1KDM4E | |
| SCHEMBL22557527 | 0.77 | L3MBTL1 (0.55) | SMN1; SMN2TP53BP1L3MBTL1KDM4EEPHX2 | |
| SCHEMBL285298 | 0.74 | SMN1; SMN2 (0.62) | TERTSMN1; SMN2L3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348023-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |