Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.64 |
| ▸ | PLG | P00747 | 4/20 | 0.64 |
| ▸ | PRKCI | P41743 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296673 | 0.86 | PLAU (0.51) | PLAUPLGPRKCIPRSS1F2 | |
| SCHEMBL8574795 | 0.82 | AR (0.64) | PRKCIMAOBTUBB4ATUBBTUBA3C | |
| SCHEMBL30098896 | 0.82 | AR (0.64) | PRKCIMAOBTUBB4ATUBBTUBA3C | |
| SCHEMBL27744167 | 0.80 | PLAU (0.61) | PLAUPLGPRSS1F2KLKB1 | |
| SCHEMBL17654485 | 0.80 | PLAU (0.61) | PLAUPLGPRSS1F2KLKB1 | |
| SCHEMBL27317702 | 0.80 | MAOB (0.54) | PLAUPLGPRKCIMAOBTUBB4A | |
| SCHEMBL12277801 | 0.79 | PRKCI (0.51) | PLAUPLGPRKCIMAOBTUBB4A | |
| SCHEMBL2414207 | 0.79 | MAOB (0.49) | PLAUPLGPRKCIMAOBTUBB4A | |
| SCHEMBL2414210 | 0.79 | PRKCI (0.51) | PLAUPLGPRKCIMAOBTUBB4A | |
| Hydrochloric Acid SCHEMBL27423848 | 0.79 | MAOB (0.53) | PLAUPLGPRKCIMAOBTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4397863-A | PROPHYLAXIS | RESEARCH TRIANGLE INSTITUTE (US) | 1983-08-09 | — | — | US | claimed |
| US-7994225-B2 | Combination of an antibiotic and a drug such as pentamidine or salts thereof to treat drug resistant eye and ear infections | REMPEX PHARMACEUTICALS, INC. (US) | 2011-08-09 | — | — | US | disclosed |
| US-7947741-B2 | Use and administration of bacterial efflux pump inhibitors | MPEX PHARMACEUTICALS, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20080132457-A1 | BACTERIAL EFFLUX PUMP INHIBITORS FOR THE TREATMENT OF OPHTHALMIC AND OTIC INFECTIONS | SILICON VALLEY BANK | 2008-06-05 | — | — | US | disclosed |
| US-20060276473-A1 | Use and administration of bacterial efflux pump inhibitors | REMPEX PHARMACEUTICALS, INC. | 2006-12-07 | — | — | US | disclosed |
| US-4619942-A | Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds | UNIVERSITY OF NORTH CAROLINA (US) | 1986-10-28 | — | — | US | disclosed |
| US-4619942-A | Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds | UNIVERSITY OF NORTH CAROLINA (US) | 1986-10-28 | — | — | US | disclosed |
| US-4397863-A | PROPHYLAXIS | RESEARCH TRIANGLE INSTITUTE (US) | 1983-08-09 | — | — | US | disclosed |
| US-4397863-A | PROPHYLAXIS | RESEARCH TRIANGLE INSTITUTE (US) | 1983-08-09 | — | — | US | disclosed |
| US-4324794-A | PREVENTION OF EPIDEMICS BY PROPHYLACTIC ADMINISTRATION | RESEARCH TRIANGLE INSTITUTE (US) | 1982-04-13 | — | — | US | disclosed |
| US-4324794-A | PREVENTION OF EPIDEMICS BY PROPHYLACTIC ADMINISTRATION | RESEARCH TRIANGLE INSTITUTE (US) | 1982-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276473-A1 | Use and administration of bacterial efflux pump inhibitors | ABCB11, ABCC1, ABCB1 | PLAU 2604/4885PLG 2961/4885PRKCI 2307/4885 |
| US-20080132457-A1 | BACTERIAL EFFLUX PUMP INHIBITORS FOR THE TREATMENT OF OPHTHALMIC AND OTIC INFECTIONS | ABCB11, SLC47A2, SLC47A1 | PLAU 2512/4885PLG 2624/4885PRKCI 3975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.