Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 9/20 | 0.61 |
| ▸ | PLG | P00747 | 5/20 | 0.61 |
| ▸ | F2 | P00734 | 3/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | KLK1 | P06870 | 1/20 | 0.48 |
| ▸ | F12 | P00748 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17654485 | 0.81 | PLAU (0.61) | PLAUPLGF2PRSS1KLKB1 | |
| SCHEMBL1817590 | 0.80 | PLAU (0.64) | PLAUPLGF2PRSS1KLKB1 | |
| SCHEMBL1816368 | 0.74 | PLAU (1.00) | PLAUPLGF2PRSS1 | |
| SCHEMBL27520653 | 0.73 | ALDH1A1 (0.53) | — | |
| SCHEMBL7533198 | 0.71 | HDAC3 (0.53) | — | |
| SCHEMBL10130424 | 0.71 | PLAU (0.72) | PLAUPLGF2PRSS1KLKB1 | |
| SCHEMBL3229590 | 0.70 | PRKCI (0.61) | PLAUF2 | |
| SCHEMBL8296673 | 0.69 | PLAU (0.51) | PLAUPLGF2PRSS1KLKB1 | |
| SCHEMBL3219394 | 0.68 | HTR2A (0.50) | — | |
| SCHEMBL1465981 | 0.68 | HTR2A (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101321525-A | Heteroaryl substituted piperidine derivatives as L-CPT1 inhibitors | HOFFMANN LA ROCHE (CH) | 2008-12-10 | — | — | CN | disclosed |