Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18176131 | 0.88 | HSD11B1 (0.55) | CCNT1CHRM3PDE4APDE4BPDE4C | |
| SCHEMBL3512955 | 0.88 | HTR3E (0.49) | PDE10ACCNT1HRH4MAPK1 | |
| SCHEMBL25893531 | 0.87 | HSD11B1 (0.53) | CCNT1CHRM3PDE4APDE4BPDE4C | |
| SCHEMBL22549300 | 0.77 | HRH4 (0.58) | HRH4CTSKPRKD1PRKD2 | |
| SCHEMBL30818932 | 0.75 | CCNT1 (0.40) | PDE10ACCNT1HRH4 | |
| SCHEMBL29632741 | 0.74 | MAPK1 (0.46) | PDE10ACCNT1PIM1MAPK1CTSK | |
| SCHEMBL15830279 | 0.74 | PDE10A (0.58) | PDE10ACCNT1PIM1MAPK1CTSK | |
| SCHEMBL25893652 | 0.74 | HRH3 (0.47) | HSD11B1HRH4CTSKTRPV3 | |
| SCHEMBL22334883 | 0.73 | GAA (0.53) | PDE10AMAPK1 | |
| SCHEMBL20688213 | 0.72 | CNR1 (0.44) | PDE10AHSD11B1TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948442-B1 | PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2016-10-26 | — | — | EP | disclosed |