Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.86 |
| ▸ | FGFR2 | P21802 | 16/20 | 0.86 |
| ▸ | FGFR3 | P22607 | 16/20 | 0.86 |
| ▸ | FGFR4 | P22455 | 15/20 | 0.86 |
| ▸ | KDR | P35968 | 13/20 | 0.86 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.79 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.79 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.79 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.79 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.79 |
| ▸ | DRD3 | P35462 | 1/20 | 0.79 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.79 |
| ▸ | ETV6 | P41212 | 1/20 | 0.79 |
| ▸ | HTR2B | P41595 | 1/20 | 0.79 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.79 |
| ▸ | FLT3 | P36888 | 4/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585583 | 0.93 | FGFR1 (0.98) | FGFR1FGFR2FGFR3FGFR4KDR | |
| Hydrochloric Acid SCHEMBL27218142 | 0.93 | FGFR1 (1.00) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL18176515 | 0.92 | FGFR1 (0.86) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL2583984 | 0.89 | FGFR1 (0.84) | FGFR1FGFR2FGFR3FGFR4KDR | |
| Erdafitinib SCHEMBL2583760 | 0.88 | FGFR1 (1.00) | FGFR1FGFR2FGFR3FGFR4KDR | |
| Erdafitinib SCHEMBL29359988 | 0.88 | FGFR1 (1.00) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL12178260 | 0.88 | FGFR1 (0.86) | FGFR1FGFR2FGFR3FGFR4KDR | |
| Erdafitinib SCHEMBL16642098 | 0.88 | FGFR3 (1.00) | FGFR1FGFR2FGFR3FGFR4KDR | |
| Erdafitinib SCHEMBL17979118 | 0.87 | FGFR3 (1.00) | FGFR1FGFR2FGFR3FGFR4KDR | |
| SCHEMBL12179221 | 0.87 | FGFR1 (0.98) | FGFR1FGFR2FGFR3FGFR4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160311800-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2016-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311800-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | PDXK, DCK, PDPK1 | FGFR1 1681/4885FGFR2 3362/4885FGFR3 2685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.