Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.55 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.52 |
| ▸ | LIPE | Q05469 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17014228 | 0.88 | SMN1; SMN2 (0.59) | ALDH1A1CYP2D6CYP2C19KDM4EGAA | |
| SCHEMBL22033972 | 0.88 | MEN1 (0.72) | ALDH1A1CYP2D6CYP2C19KDM4EGAA | |
| SCHEMBL20456429 | 0.86 | USP2 (0.65) | ALDH1A1KDM4EGAAEPHX2L3MBTL1 | |
| SCHEMBL17014229 | 0.86 | ALDH1A1 (0.56) | ALDH1A1CYP2D6CYP2C19KDM4EGAA | |
| SCHEMBL19823117 | 0.86 | MEN1 (0.54) | ALDH1A1CYP2D6CYP2C19KDM4EGAA | |
| SCHEMBL29460579 | 0.85 | MEN1 (0.62) | ALDH1A1KDM4EGAAEPHX2L3MBTL1 | |
| SCHEMBL20456436 | 0.84 | MEN1 (0.55) | ALDH1A1CYP2D6CYP2C19KDM4EGAA | |
| SCHEMBL2171815 | 0.84 | EPHX2 (0.61) | EPHX2MEN1KMT2ANPC1LIPE | |
| SCHEMBL22080777 | 0.82 | ALDH1A1 (0.70) | ALDH1A1CYP2D6CYP2C19KDM4EGAA | |
| SCHEMBL1676915 | 0.81 | EPHX2 (0.62) | ALDH1A1EPHX2MEN1KMT2ALIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160313302-A1 | TARGETING EMOPAMIL BINDING PROTEIN (EBP) WITH SMALL MOLECULES THAT INDUCE AN ABNORMAL FEEDBACK RESPONSE BY LOWERING ENDOGENOUS CHOLESTEROL BIOSYNTHESIS | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2016-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160313302-A1 | TARGETING EMOPAMIL BINDING PROTEIN (EBP) WITH SMALL MOLECULES THAT INDUCE AN ABNORMAL FEEDBACK RESPONSE BY LOWERING ENDOGENOUS CHOLESTEROL BIOSYNTHESIS | SREBF1, SREBF2, EBPL | ALDH1A1 4063/4885CYP2D6 4199/4885CYP2C19 4602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.