Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14957567 | 0.97 | CYP1A2 (0.47) | MAOACHRM2HRH4HRH3CYP1A2 | |
| SCHEMBL16781356 | 0.93 | CXCR4 (0.50) | CHRM2CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL16781357 | 0.86 | CHRM2 (0.47) | CHRM2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16812989 | 0.86 | CHRM2 (0.55) | MAOACHRM2HDAC3HDAC4HDAC1 | |
| SCHEMBL16812994 | 0.81 | HRH4 (0.55) | MAOACHRM2HRH4HRH3SIGMAR1 | |
| SCHEMBL3722162 | 0.79 | IDO1 (0.50) | CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL2237883 | 0.79 | ADRB2 (0.51) | CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL5991973 | 0.79 | ADH1B (0.55) | CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL20922146 | 0.77 | HDAC3 (0.40) | CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL12327091 | 0.77 | CCNE1 (0.46) | CYP1A2CYP2D6CYP19A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180071232-A1 | COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-03-15 | — | — | US | disclosed |
| US-20180071232-A1 | COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-03-15 | — | — | US | disclosed |
| US-9849098-B2 | Compositions and methods for treating respiratory injury or disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-12-26 | — | — | US | disclosed |
| US-9849098-B2 | Compositions and methods for treating respiratory injury or disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-12-26 | — | — | US | disclosed |
| US-20160310447-A1 | COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-10-27 | — | — | US | disclosed |
| US-20160310447-A1 | COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180071232-A1 | COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C9, C1S | MAOA 3038/4885CHRM2 647/4885HRH4 1149/4885 |
| US-20160310447-A1 | COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY INJURY OR DISEASE | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C1S, C9 | MAOA 2699/4885CHRM2 513/4885HRH4 906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.