Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18179861 | 0.79 | BAZ2B (0.46) | ALDH1A1SMN1; SMN2GAAKDM4ECA1 | |
| SCHEMBL21728685 | 0.75 | KDM4E (0.45) | SMN1; SMN2KDM4EMAPTL3MBTL1RAB9A | |
| SCHEMBL1412553 | 0.73 | TP53 (0.56) | ALDH1A1SMN1; SMN2KDM4EHSD17B10MAPT | |
| SCHEMBL3700954 | 0.72 | HTT (0.52) | ALDH1A1GAAKDM4EPTGS2NPC1 | |
| SCHEMBL12343345 | 0.72 | PTGS2 (0.47) | ALDH1A1SMN1; SMN2CA1CA2PTGS2 | |
| SCHEMBL13184415 | 0.72 | KDM4E (0.58) | ALDH1A1SMN1; SMN2GAAKDM4EMAPT | |
| SCHEMBL903084 | 0.72 | GAA (0.50) | ALDH1A1SMN1; SMN2GAAKDM4ENPSR1 | |
| SCHEMBL21621354 | 0.71 | IKBKE (0.48) | ALDH1A1SMN1; SMN2GAAKDM4ENPSR1 | |
| SCHEMBL13753976 | 0.71 | KDM4E (0.69) | ALDH1A1SMN1; SMN2GAAKDM4ENPSR1 | |
| SCHEMBL2938277 | 0.71 | PTGS2 (0.35) | ALDH1A1GAAKDM4EPTGS2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160311853-A1 | CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2016-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311853-A1 | CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF | CD47, NGLY1, VIP | ALDH1A1 3311/4885SMN1; SMN2 2012/4885GAA 583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.