Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | XBP1 | P17861 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.31 |
| ▸ | TLR4 | O00206 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10307520 | 1.00 | MAPT (0.35) | MAPTNPC1HTTRAB9AXBP1 | |
| Grossheimin SCHEMBL1711489 | 0.81 | MAPT (0.34) | MAPTNPC1HTTRAB9AXBP1 | |
| Grossheimin SCHEMBL1711493 | 0.81 | MAPT (0.34) | MAPTNPC1HTTRAB9AXBP1 | |
| SCHEMBL22305507 | 0.80 | PKM (0.41) | MAPTNPC1HTTRAB9APTGS2 | |
| SCHEMBL31273011 | 0.78 | MAPT (0.42) | MAPTNPC1HTTRAB9AALDH1A1 | |
| SCHEMBL10307512 | 0.78 | MAPT (0.42) | MAPTNPC1HTTRAB9AALDH1A1 | |
| SCHEMBL22422628 | 0.78 | MAPT (0.36) | MAPTNPC1HTTRAB9AALDH1A1 | |
| SCHEMBL10307521 | 0.77 | MAPK1 (0.41) | MAPK1TLR4 | |
| Desacylcynaropicrin SCHEMBL10307509 | 0.75 | MAPT (0.33) | MAPTNPC1HTTRAB9AXBP1 | |
| Desacylcynaropicrin SCHEMBL1712162 | 0.75 | MAPT (0.33) | MAPTNPC1HTTRAB9AXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016169573-A1 | SESQUITERPENE LACTONES AS POTENT AND BROAD SPECTRUM ANTIVIRAL COMPOUNDS AGAINST ALL GENOTYPES OF HEPATITIS C VIRUS (HCV) | ELSEBAI MAHMOUD FAHMI (EG) | 2016-10-27 | — | — | WO | disclosed |