Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.50 |
| ▸ | GAA | P10253 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MC4R | P32245 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15349719 | 0.89 | MAPT (0.62) | MAPTGAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL15349379 | 0.81 | LMNA (0.52) | MAPTGAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL18181685 | 0.81 | KDM4E (0.51) | MAPTGAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL18181563 | 0.79 | MAPT (0.51) | MAPTGAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL18171846 | 0.79 | EGFR (0.50) | MAPTGAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL1014395 | 0.77 | MAPT (0.74) | MAPTGAATDP1L3MBTL1LMNA | |
| SCHEMBL10782873 | 0.76 | MAPT (0.61) | MAPTGAASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL15349377 | 0.76 | KDM4E (0.49) | MAPTGAATDP1L3MBTL1LMNA | |
| SCHEMBL10787999 | 0.76 | PDE4B (0.51) | MAPTGAASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL10781736 | 0.74 | MAPT (0.54) | MAPTGAASMN1; SMN2L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364247-B2 | Preparation and use of novel protein kinase inhibitors | RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE (CN) | 2019-07-30 | — | — | US | disclosed |
| US-20180105528-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | BRANDEIS UNIVERSITY | 2018-04-19 | — | — | US | disclosed |
| WO-2016168992-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE (CN) | 2016-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10364247-B2 | Preparation and use of novel protein kinase inhibitors | MAP3K20, MAP3K19, MAP3K5 | MAPT 2497/4885GAA 3242/4885SMN1; SMN2 3560/4885 |
| US-20180105528-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K5 | MAPT 2497/4885GAA 3242/4885SMN1; SMN2 3560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.