Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16792647 | 0.86 | ALDH1A1 (0.42) | TRPA1LMNAGAAEGLN1F10 | |
| SCHEMBL16814432 | 0.85 | TRPA1 (0.41) | TRPA1LMNAGAAHTTMAPK1 | |
| Hydrochloric Acid SCHEMBL16792572 | 0.84 | TRPA1 (0.40) | TRPA1LMNAGAAHTTMAPK1 | |
| SCHEMBL18181864 | 0.84 | HTR2A (0.49) | TRPA1LMNAGAAHTTSLC6A4 | |
| SCHEMBL21572218 | 0.83 | TRPA1 (0.39) | TRPA1GAAEGLN1F10SLC6A4 | |
| SCHEMBL18331726 | 0.83 | TRPA1 (0.39) | TRPA1LMNAGAAHTTMAPK1 | |
| SCHEMBL16792417 | 0.80 | GAA (0.44) | TRPA1GAAF10SLC6A4HTR2A | |
| SCHEMBL16792375 | 0.80 | TRPA1 (0.39) | TRPA1GAAEGLN1F10SLC6A4 | |
| SCHEMBL16792679 | 0.80 | ALDH1A1 (0.46) | EGLN1MAPTSMN1; SMN2NPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL16792418 | 0.79 | TRPA1 (0.39) | TRPA1GAAEGLN1F10SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556150-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMANN-LA ROCHE INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20160311801-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | CHUGAI PHARMACEUTICAL CO. (JP) | 2016-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311801-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, SYK, LYN | TRPA1 2395/4885LMNA 4107/4885GAA 637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.