Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CNKSR1 | Q969H4 | 5/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18148074 | 0.83 | CNKSR1 (0.60) | TP53CNKSR1AKT1ALDH1A1HIF1A | |
| SCHEMBL18147978 | 0.82 | ALDH1A1 (0.42) | TP53CNKSR1AKT1ALDH1A1HIF1A | |
| SCHEMBL17211658 | 0.75 | CNKSR1 (0.60) | CNKSR1AKT1ALDH1A1HIF1AMEN1 | |
| SCHEMBL15888942 | 0.75 | CNKSR1 (0.65) | TP53CNKSR1AKT1ALDH1A1HIF1A | |
| SCHEMBL10058097 | 0.74 | BRAF (0.56) | CNKSR1AKT1ALDH1A1MEN1KMT2A | |
| SCHEMBL15811516 | 0.72 | CNKSR1 (0.67) | CNKSR1AKT1ALDH1A1HIF1AMEN1 | |
| SCHEMBL15811503 | 0.71 | CNKSR1 (0.62) | CNKSR1AKT1ALDH1A1HIF1AMEN1 | |
| SCHEMBL2354908 | 0.71 | MEN1 (0.53) | TP53CNKSR1AKT1ALDH1A1HIF1A | |
| SCHEMBL7572736 | 0.71 | TP53 (0.59) | TP53ALDH1A1KMT2AHPGDTSHR | |
| SCHEMBL1653275 | 0.71 | HIF1A (0.51) | TP53CNKSR1AKT1ALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016172191-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2016-10-27 | — | — | WO | disclosed |