Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 9/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6121888 | 0.89 | POLB (0.62) | POLBTDP1CHRM2CHRM1CHRM3 | |
| SCHEMBL6122705 | 0.87 | CHRM2 (0.53) | POLBTDP1CHRM2CHRM1CHRM3 | |
| SCHEMBL16762167 | 0.85 | POLB (0.52) | POLBTDP1CHRM2CHRM1CHRM3 | |
| SCHEMBL4080378 | 0.84 | POLB (0.69) | POLBTDP1ALDH1A1TRPM8TSHR | |
| SCHEMBL20211082 | 0.82 | RIPK1 (0.51) | POLBTDP1CHRM2CHRM1CHRM3 | |
| SCHEMBL6121893 | 0.81 | POLB (0.58) | POLBTDP1CHRM2CHRM1CHRM3 | |
| SCHEMBL6121684 | 0.81 | TRPM8 (0.62) | POLBTDP1ALDH1A1TRPM8TSHR | |
| SCHEMBL12810890 | 0.79 | POLB (0.56) | POLBTDP1ALDH1A1TRPM8TSHR | |
| Hydrochloric Acid SCHEMBL6121793 | 0.79 | TRPM8 (0.61) | POLBTDP1ALDH1A1TRPM8TSHR | |
| SCHEMBL6122454 | 0.79 | RIPK1 (0.48) | POLBTDP1CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2640721-B1 | AGONISTS THAT ENHANCE BINDING OF INTEGRIN-EXPRESSING CELLS TO INTEGRIN RECEPTORS | TEXAS HEART INST (US) | 2018-06-06 | — | — | EP | claimed |
| EP-2881393-B1 | Agonists that enhance binding of integrin-expressing cells to integrin receptors | TEXAS HEART INST (US) | 2018-06-06 | — | — | EP | disclosed |
| EP-3288585-A2 | NOVEL COMPOSITIONS AND METHODS FOR IMMUNOTHERAPIES COMPRISING SMALL MOLECULE INTEGRIN RECEPTOR-LIGAND AGONIST ADJUVANTS | 7 HILLS INTERESTS, LLC (US) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016176400-A2 | NOVEL COMPOSITIONS AND METHODS FOR IMMUNOTHERAPIES COMPRISING SMALL MOLECULE INTEGRIN RECEPTOR-LIGAND AGONIST ADJUVANTS | 7 HILLS INTERESTS LLC (US) | 2016-11-03 | — | — | WO | disclosed |