SCHEMBL1819124

SCHEMBL1819124

CCc1[c]c(Cc2ccccc2)n[nH]1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.39
TSHR P16473 1/20 0.39
TP53 P04637 1/20 0.39
TDP1 Q9NUW8 1/20 0.38
CALM1 P0DP23 1/20 0.37
DAO P14920 1/20 0.37
NR1H2 P55055 1/20 0.37
NR1H3 Q13133 1/20 0.37
RAB9A P51151 2/20 0.36
NPC1 O15118 1/20 0.36
POLB P06746 1/20 0.36
ALDH1A1 P00352 4/20 0.36
ALOX12 P18054 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
PARP1 P09874 1/20 0.36
AR P10275 1/20 0.36
CYP2C9 P11712 1/20 0.35
GFER P55789 1/20 0.35
HCAR2 Q8TDS4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1821061 0.79 NR1H2 (0.42) HPGDTSHRCALM1DAONR1H2
SCHEMBL458788 0.75 BTK (0.36) HPGDTP53NR1H2NR1H3RAB9A
SCHEMBL23674812 0.71 NR1H2 (0.42) HPGDTSHRCALM1DAONR1H2
SCHEMBL3924743 0.63 CALM1 (0.42) HPGDTSHRCALM1DAONR1H2
SCHEMBL5076428 0.62 CALM1 (0.41) HPGDCALM1NR1H2NR1H3RAB9A
SCHEMBL7385670 0.62 GAA (0.44) TSHRCALM1DAONR1H2NR1H3
SCHEMBL5031564 0.61 TP53 (0.78) TP53CALM1RAB9ANPC1POLB
SCHEMBL12877777 0.61 GAA (0.47) TP53CALM1DAONR1H2NR1H3
SCHEMBL29271 0.61 CALM1 (0.44) HPGDTSHRCALM1RAB9ANPC1
Diphenylmethane SCHEMBL5962570 0.60 CALM1 (0.75) TSHRTP53CALM1ALDH1A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4688381-B2 2011-05-25 JP claimed
EP-1192133-A1 N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2002-04-03 EP claimed
WO-2000076972-A1 N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-12-21 WO claimed
WO-2000076511-A1 CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-12-21 WO claimed
WO-2000076514-A1 CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-12-21 WO claimed
EP-1469849-A4 TREATING STRESS RESPONSE WITH CHEMOKINE RECEPTOR CCR5 MODULATORS MERCK & CO INC (US) 2007-06-27 EP disclosed
EP-1469849-A1 TREATING STRESS RESPONSE WITH CHEMOKINE RECEPTOR CCR5 MODULATORS Merck & Co., Inc. (US) 2004-10-27 EP disclosed
WO-2003061659-A1 TREATING STRESS RESPONSE WITH CHEMOKINE RECEPTOR CCR5 MODULATORS MERCK & CO., INC. (US) 2003-07-31 WO disclosed
EP-1192133-A1 N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2002-04-03 EP disclosed
WO-2000076972-A1 N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-12-21 WO disclosed
WO-2000076514-A1 CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-12-21 WO disclosed