Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.69 |
| ▸ | MEN1 | O00255 | 7/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.66 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.66 |
| ▸ | P4HB | P07237 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20608072 | 0.89 | LMNA (0.64) | LMNAKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL609304 | 0.87 | KDM4E (0.79) | LMNAKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL4864670 | 0.86 | L3MBTL1 (0.77) | LMNAKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL26102667 | 0.86 | LMNA (0.69) | LMNAKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL3317836 | 0.85 | LMNA (0.68) | LMNAKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL31643319 | 0.84 | KMT2A (0.67) | LMNAKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL7012242 | 0.84 | LMNA (0.67) | LMNAKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL15353093 | 0.83 | LMNA (0.65) | LMNAKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL13118614 | 0.82 | LMNA (0.65) | LMNAKMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL4609435 | 0.82 | CYP3A4 (0.65) | LMNAKMT2AMEN1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2877471-B1 | SPIRO-FUSED PIPERIDINE DERIVATIVES FOR USE AS INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2016-11-02 | — | — | EP | disclosed |