Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | MPI | P34949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374599 | 0.83 | ALDH1A1 (0.42) | ALDH1A1DPP4DPP8DPP7KDM4E | |
| SCHEMBL3151430 | 0.78 | CA1 (0.49) | CA1CA2MPI | |
| SCHEMBL3355222 | 0.76 | — | — | |
| SCHEMBL13275068 | 0.75 | KDM4E (0.38) | ALDH1A1DPP4DPP8DPP7KDM4E | |
| SCHEMBL185561 | 0.73 | — | — | |
| SCHEMBL52596 | 0.71 | — | — | |
| SCHEMBL22436525 | 0.71 | PTPN1 (0.41) | ALDH1A1DPP4DPP8DPP7KDM4E | |
| Hydrochloric Acid SCHEMBL22436543 | 0.71 | PTPN1 (0.41) | ALDH1A1DPP4DPP8DPP7KDM4E | |
| SCHEMBL9631392 | 0.71 | KDM4E (0.40) | ALDH1A1DPP4DPP8DPP7KDM4E | |
| Potassium Ion SCHEMBL52283 | 0.70 | KDM4E (0.31) | ALDH1A1DPP4DPP8DPP7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231621-B1 | PROCESS FOR PREPARING N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDES | MERCK SHARP & DOHME (US) | 2016-11-02 | — | — | EP | disclosed |