Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 9/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175868 | 0.80 | MAPK3 (0.57) | MAPK3MAPK1CYP3A4 | |
| SCHEMBL18197030 | 0.60 | SSTR4 (0.37) | — | |
| SCHEMBL18197025 | 0.60 | NAMPT (0.39) | HTTALDH1A1LMNA | |
| SCHEMBL1146843 | 0.59 | MEN1 (0.53) | MAPK1NPY2RMEN1KMT2AHTT | |
| SCHEMBL1147148 | 0.59 | MEN1 (0.52) | MAPK1NPY2RMEN1KMT2AHTT | |
| SCHEMBL18197001 | 0.59 | MAP2K1 (0.33) | LMNA | |
| SCHEMBL173270 | 0.58 | MAPK1 (0.60) | MAPK3MAPK1 | |
| SCHEMBL1147231 | 0.58 | MEN1 (0.51) | MAPK1NPY2RMEN1KMT2AHTT | |
| SCHEMBL12875147 | 0.58 | MEN1 (0.51) | MAPK1NPY2RMEN1KMT2AHTT | |
| Hydrochloric Acid SCHEMBL1146741 | 0.58 | MEN1 (0.50) | MAPK1NPY2RMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613782-B1 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2016-11-02 | — | — | EP | disclosed |