Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12874912 | 0.89 | FAAH (0.48) | MEN1KMT2AKDM4EALDH1A1SSTR5 | |
| SCHEMBL12874924 | 0.82 | MEN1 (0.45) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL12875690 | 0.80 | CHRNB2 (0.50) | MEN1KMT2AALDH1A1MAPK1MAPT | |
| SCHEMBL1146843 | 0.77 | MEN1 (0.53) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL1147148 | 0.76 | MEN1 (0.52) | MEN1KMT2AHTTKDM4EALDH1A1 | |
| SCHEMBL12875314 | 0.76 | KDM4E (0.47) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL12874915 | 0.74 | EPHX2 (0.52) | KMT2AHTTALDH1A1NPY2RRAB9A | |
| SCHEMBL1147265 | 0.74 | P2RY1 (0.48) | MEN1KMT2AHTTKDM4ENPY2R | |
| SCHEMBL12875143 | 0.73 | CNR2 (0.49) | TP53 | |
| SCHEMBL1147231 | 0.73 | MEN1 (0.51) | MEN1KMT2AHTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012602-A1 | PIPERIDINE DERIVATIVES AND THEIR USE TO TREAT OBESITY, DIABETES, DYSLIPIDEMIA AND ATHEROSCLEROSIS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-02-03 | — | — | WO | disclosed |