Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 3/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18197001 | 0.80 | MAP2K1 (0.33) | — | |
| SCHEMBL18197039 | 0.76 | PORCN (0.37) | SLC6A3 | |
| SCHEMBL168798 | 0.75 | LRRK2 (0.50) | — | |
| SCHEMBL18197025 | 0.74 | NAMPT (0.39) | — | |
| SCHEMBL11203028 | 0.71 | NFKB1 (0.51) | SLC6A3 | |
| SCHEMBL13910696 | 0.69 | ALDH1A1 (0.51) | SSTR4TAAR1 | |
| SCHEMBL1318306 | 0.69 | SSTR4 (0.51) | SSTR4 | |
| SCHEMBL21669843 | 0.69 | SLC6A2 (0.51) | — | |
| SCHEMBL13910693 | 0.68 | NPC1 (0.56) | — | |
| SCHEMBL23303999 | 0.68 | CHRNB2 (0.42) | SSTR4TAAR1SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613782-B1 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2016-11-02 | — | — | EP | disclosed |