Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2495818 | 0.77 | MET (0.67) | MET | |
| SCHEMBL19338390 | 0.74 | MET (0.63) | MET | |
| SCHEMBL18197862 | 0.73 | MET (0.60) | MET | |
| SCHEMBL18197881 | 0.71 | MET (0.55) | MET | |
| SCHEMBL18197850 | 0.71 | MET (0.46) | MET | |
| SCHEMBL19338425 | 0.70 | MET (0.49) | MET | |
| SCHEMBL1659800 | 0.69 | MET (0.43) | MET | |
| SCHEMBL10838270 | 0.69 | CYP2A6 (0.50) | CYP2A6PDE10A | |
| SCHEMBL19338408 | 0.69 | MET (0.35) | MET | |
| SCHEMBL18197888 | 0.68 | MET (0.41) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B9 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-13 | — | — | EP | disclosed |
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |