Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204833 | 1.00 | MEN1 (0.52) | MEN1KMT2APKMKDM4EMAPT | |
| SCHEMBL20186695 | 0.74 | ABCB1 (0.38) | MEN1KMT2AKDM4EMAPTPOLB | |
| SCHEMBL18201257 | 0.73 | ABCB1 (0.35) | KDM4EABCB1ABCG2 | |
| SCHEMBL10856970 | 0.70 | KIF11 (0.54) | MEN1KMT2AKDM4EMAPTPOLB | |
| SCHEMBL10859605 | 0.70 | ABCG2 (0.54) | MEN1KMT2AKDM4EMAPTPOLB | |
| SCHEMBL11115155 | 0.69 | ABCG2 (0.53) | MEN1KMT2AKDM4EMAPTPOLB | |
| SCHEMBL10857916 | 0.69 | ABCB1 (0.50) | MEN1KMT2APKMKDM4EMAPT | |
| SCHEMBL10855792 | 0.69 | ABCG2 (0.52) | MEN1KMT2AKDM4EMAPTPOLB | |
| SCHEMBL10855318 | 0.68 | KDM4E (0.52) | MEN1KMT2AKDM4EMAPTPOLB | |
| SCHEMBL10815662 | 0.68 | ABCG2 (0.52) | MEN1KMT2AKDM4EMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288921-B1 | POLYCYCLIC INDOLINE AND INDOLENINE COMPOUNDS | UNIV COLORADO REGENTS (US) | 2022-06-15 | — | — | EP | disclosed |
| US-10253024-B2 | Polycyclic indoline and indolenine compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2019-04-09 | — | — | US | disclosed |
| US-20180148442-A1 | Polycyclic Indoline and Indolenine Compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2018-05-31 | — | — | US | disclosed |
| US-20180148442-A1 | Polycyclic Indoline and Indolenine Compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2018-05-31 | — | — | US | disclosed |
| WO-2016176634-A1 | POLYCYCLIC INDOLINE AND INDOLENINE COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10253024-B2 | Polycyclic indoline and indolenine compounds | IDO1, IDO2, INMT | MEN1 760/4885KMT2A 1088/4885PKM 4034/4885 |
| US-20180148442-A1 | Polycyclic Indoline and Indolenine Compounds | IDO1, IDO2, INMT | MEN1 760/4885KMT2A 1088/4885PKM 4034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.