Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | ARG1 | P05089 | 4/20 | 0.42 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | ARG2 | P78540 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL162687 | 1.00 | MEN1 (0.52) | MEN1BLMKMT2ASLC1A2ARG1 | |
| Proline SCHEMBL4398037 | 0.91 | MEN1 (0.44) | MEN1BLMKMT2ASLC1A2ARG1 | |
| Proline SCHEMBL28467818 | 0.91 | MEN1 (0.44) | MEN1BLMKMT2ASLC1A2ARG1 | |
| Proline SCHEMBL1196246 | 0.91 | MEN1 (0.44) | MEN1BLMKMT2ASLC1A2ARG1 | |
| Proline SCHEMBL10979350 | 0.88 | MEN1 (0.41) | MEN1BLMKMT2ASLC1A2ARG1 | |
| Proline SCHEMBL10828992 | 0.86 | MEN1 (0.40) | MEN1BLMKMT2ASLC1A2ARG1 | |
| SCHEMBL351910 | 0.85 | MEN1 (0.63) | MEN1BLMKMT2ASLC1A2ARG1 | |
| SCHEMBL12909421 | 0.85 | MEN1 (0.63) | MEN1BLMKMT2ASLC1A2ARG1 | |
| SCHEMBL2964298 | 0.85 | MEN1 (0.63) | MEN1BLMKMT2ASLC1A2ARG1 | |
| SCHEMBL17943259 | 0.85 | MEN1 (0.63) | MEN1BLMKMT2ASLC1A2ARG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210038564-A1 | METHODS FOR SCAR PREVENTION | NORTHWESTERN UNIVERSITY | 2021-02-11 | — | — | US | claimed |
| US-20170119732-A1 | METHODS FOR SCAR PREVENTION | NORTHWESTERN UNIVERSITY | 2017-05-04 | — | — | US | claimed |
| US-20110105996-A1 | METHODS FOR SCAR PREVENTION | NORTHWESTERN UNIVERSITY (US) | 2011-05-05 | — | — | US | claimed |
| US-11890290-B2 | Topical treatment of wounds with statins and cholesterol for scar reduction | NORTHWESTERN UNIVERSITY (US) | 2024-02-06 | — | — | US | disclosed |
| US-20220133743-A1 | TOPICAL TREATMENT OF WOUNDS WITH STATINS AND CHOLESTEROL FOR SCAR REDUCTION | UNITED STATES GOVERNMENT | 2022-05-05 | — | — | US | disclosed |
| US-11065262-B2 | Topical treatment of wounds with statins and cholesterol for scar reduction | NORTHWESTERN UNIVERSITY (US) | 2021-07-20 | — | — | US | disclosed |
| US-20210038564-A1 | METHODS FOR SCAR PREVENTION | NORTHWESTERN UNIVERSITY | 2021-02-11 | — | — | US | disclosed |
| US-20190030045-A1 | TOPICAL TREATMENT OF WOUNDS WITH STATINS AND CHOLESTEROL FOR SCAR REDUCTION | NORTHWESTERN UNIVERSITY | 2019-01-31 | — | — | US | disclosed |
| US-20170119732-A1 | METHODS FOR SCAR PREVENTION | NORTHWESTERN UNIVERSITY | 2017-05-04 | — | — | US | disclosed |
| CN-105543265-A | Method for effectively improving proline conversion rate in system for producing Cis-3-hydroxy-L-proline according to biosynthesis method | UNIV JIANGNAN | 2016-05-04 | — | — | CN | disclosed |
| US-20110105996-A1 | METHODS FOR SCAR PREVENTION | NORTHWESTERN UNIVERSITY (US) | 2011-05-05 | — | — | US | disclosed |