Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | ARG1 | P05089 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL1820143 | 0.86 | MEN1 (0.52) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL162687 | 0.86 | MEN1 (0.52) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL28467818 | 0.81 | MEN1 (0.44) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL1196246 | 0.81 | MEN1 (0.44) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL4398037 | 0.81 | MEN1 (0.44) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL10979350 | 0.78 | MEN1 (0.41) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL7447947 | 0.77 | MEN1 (0.42) | MEN1BLMKMT2AELANECTSC | |
| Biphenyl SCHEMBL2308811 | 0.75 | ELANE (0.47) | MEN1BLMKMT2AELANECTSC | |
| Proline SCHEMBL16394427 | 0.74 | BLM (0.48) | MEN1BLMKMT2AELANECTSC | |
| Questiomycin B SCHEMBL27740312 | 0.73 | ALOX15 (0.46) | ELANECTSCSCN4ADPP4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4590178-A | DIURETICS | AJINOMOTO COMPANY, INCORPORATED (JP) | 1986-05-20 | — | — | US | disclosed |