Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 11/20 | 0.39 |
| ▸ | PER2 | O15055 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18202161 | 0.88 | PER2 (0.41) | KCNK3PER2CRY2PIK3CAPIK3CB | |
| SCHEMBL19921337 | 0.82 | KCNK3 (0.36) | KCNK3PER2MAPK8MAPK9CRY2 | |
| SCHEMBL19930207 | 0.78 | HTR2A (0.53) | ALDH1A1KDM4EHTR2AHTR2C | |
| SCHEMBL19921257 | 0.77 | LPL (0.34) | KCNK3PER2CRY2HTR7 | |
| SCHEMBL18540624 | 0.73 | HTR2A (0.58) | PIK3CAPIK3CBPIK3CGKDM4EHTR2A | |
| SCHEMBL18202353 | 0.73 | PER2 (0.40) | KCNK3PER2CRY2PIK3CAPIK3CB | |
| SCHEMBL19960991 | 0.73 | PER2 (0.44) | KCNK3PER2CRY2PIK3CAPIK3CB | |
| SCHEMBL31487332 | 0.70 | PER2 (0.38) | KCNK3PER2CRY2ALDH1A1KDM4E | |
| SCHEMBL18202302 | 0.70 | CSNK1D (0.32) | KCNK3PER2CRY2PIK3CAPIK3CB | |
| SCHEMBL31487078 | 0.70 | PER2 (0.38) | KCNK3PER2CRY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290419-B1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-08-07 | — | — | EP | disclosed |
| EP-3312179-A1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-04-25 | — | — | EP | disclosed |
| EP-3290419-A1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016173438-A1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | 南京明德新药研发股份有限公司 | 2016-11-03 | — | — | WO | disclosed |