Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 9/20 | 0.51 |
| ▸ | CACNG8 | Q8WXS5 | 9/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | CDC25C | P30307 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20838856 | 0.89 | GRIA1 (0.65) | GRIA1CACNG8HDAC4HDAC2HDAC8 | |
| SCHEMBL18203057 | 0.74 | GRIA1 (0.66) | GRIA1CACNG8 | |
| SCHEMBL18190577 | 0.73 | GRIA1 (0.81) | GRIA1CACNG8ABL1ABCB1 | |
| SCHEMBL5788217 | 0.73 | ALDH1A1 (0.56) | GRIA1CACNG8HDAC4HDAC8 | |
| SCHEMBL18203047 | 0.72 | GRIA1 (0.69) | GRIA1CACNG8CDC25ACDC25BCDC25C | |
| SCHEMBL18190672 | 0.72 | GRIA1 (0.69) | GRIA1CACNG8 | |
| SCHEMBL17731629 | 0.72 | MAP2K1 (0.47) | HDAC4HDAC2HDAC8MAP2K1PARP1 | |
| SCHEMBL18190597 | 0.71 | GRIA1 (0.61) | GRIA1CACNG8TEK | |
| SCHEMBL18203023 | 0.71 | GRIA1 (0.75) | GRIA1CACNG8 | |
| SCHEMBL18190614 | 0.71 | GRIA1 (0.75) | GRIA1CACNG8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016176449-A1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-03 | — | — | WO | disclosed |