Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823516 | 0.86 | PPARA (0.45) | NPC1RAB9AHTTSMN1; SMN2MEN1 | |
| SCHEMBL1824799 | 0.79 | MCL1 (0.45) | NPC1RAB9AHTTMEN1KMT2A | |
| SCHEMBL1819391 | 0.78 | NPC1 (0.43) | NPC1RAB9AHTTSMN1; SMN2MEN1 | |
| SCHEMBL1822481 | 0.78 | BCHE (0.48) | RAB9ASMN1; SMN2L3MBTL1MEN1KMT2A | |
| SCHEMBL1821326 | 0.78 | PPARG (0.45) | SMN1; SMN2KIF11L3MBTL1MEN1KMT2A | |
| SCHEMBL1820649 | 0.76 | KIF11 (0.45) | SMN1; SMN2KIF11PPARGPPARAALDH1A1 | |
| SCHEMBL1820277 | 0.75 | PPARG (0.47) | NPC1RAB9AHTTSMN1; SMN2RECQL | |
| SCHEMBL1818707 | 0.73 | PPARA (0.47) | NPC1RAB9AHTTSMN1; SMN2MEN1 | |
| SCHEMBL1818640 | 0.72 | HDAC3 (0.58) | NPC1RAB9AKCNN4CASP3SENP7 | |
| SCHEMBL1819039 | 0.72 | PPARA (0.46) | NPC1RAB9AHTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947712-B2 | Antiarthritic agents; asthma; chronic obstructive pulminary diosrders; atherosclerosis; vision defects; hepatitis; central nervous system disorders; cardiovascular disorders; wound healing agents; restenosis; cirrhosis; multiple sclerosis; glomerulonephritis; graft versus host disease; antidiabetic agent | WYETH LLC (US) | 2011-05-24 | — | — | US | disclosed |