Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 10/20 | 0.45 |
| ▸ | PPARG | P37231 | 9/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | FABP2 | P12104 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823516 | 0.85 | PPARA (0.45) | PPARAPPARGALDH1A1FABP2SMN1; SMN2 | |
| SCHEMBL1821326 | 0.79 | PPARG (0.45) | KIF11PPARAPPARGALDH1A1SMN1; SMN2 | |
| SCHEMBL1820464 | 0.76 | NPC1 (0.42) | KIF11PPARAPPARGALDH1A1SMN1; SMN2 | |
| SCHEMBL1824799 | 0.74 | MCL1 (0.45) | PPARAPPARGALDH1A1KDM4EMAPT | |
| SCHEMBL1818640 | 0.71 | HDAC3 (0.58) | PPARAPPARG | |
| SCHEMBL1819039 | 0.71 | PPARA (0.46) | PPARAPPARGALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1822481 | 0.71 | BCHE (0.48) | PPARAPPARGALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1818949 | 0.70 | KDM4E (0.44) | PPARAPPARGALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1821867 | 0.70 | PPARA (0.45) | PPARAPPARGALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1819315 | 0.70 | ALDH1A1 (0.40) | PPARAPPARGALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947712-B2 | Antiarthritic agents; asthma; chronic obstructive pulminary diosrders; atherosclerosis; vision defects; hepatitis; central nervous system disorders; cardiovascular disorders; wound healing agents; restenosis; cirrhosis; multiple sclerosis; glomerulonephritis; graft versus host disease; antidiabetic agent | WYETH LLC (US) | 2011-05-24 | — | — | US | disclosed |