SCHEMBL18205191

SCHEMBL18205191

O=C(O)c1ccc(-c2noc(C(F)(F)F)n2)c(F)c1

nearest known ligand 0.55

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 16/20 0.55
HDAC1 Q13547 15/20 0.55
HDAC5 Q9UQL6 13/20 0.55
HDAC8 Q9BY41 10/20 0.55
HDAC4 P56524 4/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29712282 1.00 HDAC6 (0.55) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL27152631 0.88 RARB (0.48) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL19384961 0.88 HDAC1 (0.65) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL29712264 0.88 HDAC1 (0.65) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL18205159 0.85 HDAC4 (0.52) HDAC6HDAC8HDAC4
SCHEMBL28506632 0.84 HDAC1 (0.51) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL21125023 0.84 HDAC6 (0.53) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL21330353 0.83 HDAC4 (0.69) HDAC6HDAC1HDAC5HDAC8HDAC4
SCHEMBL19384927 0.82 HDAC1 (0.51) HDAC6HDAC1HDAC5HDAC8
SCHEMBL25312552 0.81 HDAC6 (0.52) HDAC6HDAC1HDAC5HDAC8HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3291810-B1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION INC (US) 2022-08-10 EP disclosed
CN-109071520-B Microbicidal oxadiazole derivatives 先正达参股股份有限公司 2022-06-14 CN disclosed
US-11192867-B2 Microbiocidal oxadiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2021-12-07 US disclosed
CN-107735088-B Histone deacetylase inhibitors, compositions and methods of use thereof CHDI基金会股份有限公司 2021-11-02 CN disclosed
EP-3433252-B1 MICROBICIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2021-10-27 EP disclosed
CN-107735087-B Histone deacetylase inhibitors, compositions and methods of use thereof CHDI基金会股份有限公司 2021-09-03 CN disclosed
US-11083196-B2 Microbiocidal oxadiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2021-08-10 US disclosed
EP-3464251-B1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2021-03-03 EP disclosed
US-10757941-B2 Microbiocidal oxadiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-09-01 US disclosed
US-10757941-B2 Microbiocidal oxadiazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-09-01 US disclosed
WO-2017207757-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-12-07 WO disclosed
WO-2017162868-A1 MICROBIOCIDAL OXADIAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-09-28 WO disclosed
US-20160333001-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION, INC. 2016-11-17 US disclosed
US-20160333001-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION, INC. 2016-11-17 US disclosed
WO-2016179554-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION, INC. (US) 2016-11-10 WO disclosed
WO-2016179550-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION, INC. (US) 2016-11-10 WO disclosed
WO-2016179550-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION, INC. (US) 2016-11-10 WO disclosed
WO-2016179554-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION, INC. (US) 2016-11-10 WO disclosed
US-20160326124-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION, INC. 2016-11-10 US disclosed
US-20160326124-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF CHDI FOUNDATION, INC. 2016-11-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11083196-B2 Microbiocidal oxadiazole derivatives PRF1, NOX1, ARG1 HDAC6 610/4885HDAC1 551/4885HDAC5 1156/4885
US-11192867-B2 Microbiocidal oxadiazole derivatives PRF1, NOX1, ARG2 HDAC6 611/4885HDAC1 584/4885HDAC5 1226/4885
US-20160333001-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF HDAC1, HDAC7, HDAC5 HDAC6 9/4885HDAC1 1/4885HDAC5 3/4885
US-10757941-B2 Microbiocidal oxadiazole derivatives PRF1, NOX1, ARG1 HDAC6 610/4885HDAC1 551/4885HDAC5 1156/4885
US-20160326124-A1 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF HDAC1, HDAC7, HDAC5 HDAC6 9/4885HDAC1 1/4885HDAC5 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.