Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 7/20 | 0.54 |
| ▸ | TPO | P07202 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.31 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18205711 | 0.99 | MPO (0.53) | MPOTPOMAPK1GAAPTGDR2 | |
| SCHEMBL14936362 | 0.88 | MPO (0.57) | MPOTPOMAPK1GAAPTGDR2 | |
| SCHEMBL18205709 | 0.86 | MPO (0.46) | MPOTPOMAPK1GAAPTGDR2 | |
| SCHEMBL14936679 | 0.86 | MPO (0.57) | MPOTPOMAPK1GAAL3MBTL1 | |
| SCHEMBL14947043 | 0.86 | MPO (0.69) | MPOTPOMAPK1GAAHPGD | |
| Hydrochloric Acid SCHEMBL14936241 | 0.85 | MPO (0.56) | MPOTPOMAPK1GAAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL14936854 | 0.85 | MPO (0.67) | MPOTPOMAPK1GAAHPGD | |
| SCHEMBL14936729 | 0.82 | MPO (0.45) | MPOTPOMAPK1GAAHPGD | |
| SCHEMBL18205717 | 0.81 | MPO (0.42) | MPOTPOPTGDR2ALDH1A1KDM4E | |
| SCHEMBL14936977 | 0.81 | MPO (0.69) | MPOTPOMAPK1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771332-B2 | 2-thiopyrimidinones | PFIZER INC. (US) | 2017-09-26 | — | — | US | claimed |
| US-20160326121-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. | 2016-11-10 | — | — | US | claimed |
| US-20170275257-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170275257-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170275257-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. (US) | 2017-09-28 | — | — | US | disclosed |
| US-9771332-B2 | 2-thiopyrimidinones | PFIZER INC. (US) | 2017-09-26 | — | — | US | disclosed |
| US-9771332-B2 | 2-thiopyrimidinones | PFIZER INC. (US) | 2017-09-26 | — | — | US | disclosed |
| US-9771332-B2 | 2-thiopyrimidinones | PFIZER INC. (US) | 2017-09-26 | — | — | US | disclosed |
| WO-2016178113-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. (US) | 2016-11-10 | — | — | WO | disclosed |
| US-20160326121-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. | 2016-11-10 | — | — | US | disclosed |
| US-20160326121-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. | 2016-11-10 | — | — | US | disclosed |
| US-20160326121-A1 | 2-THIOPYRIMIDINONES | PFIZER INC. | 2016-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326121-A1 | 2-THIOPYRIMIDINONES | MPO, SERPINB1, TNNI3 | MPO 1/4885TPO 32/4885MAPK1 2615/4885 |
| US-20170275257-A1 | 2-THIOPYRIMIDINONES | MPO, SERPINB1, TNNI3 | MPO 1/4885TPO 32/4885MAPK1 2615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.