Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNTT | P04053 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | POLA1 | P09884 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28422694 | 0.76 | — | — | |
| SCHEMBL6015239 | 0.74 | — | — | |
| SCHEMBL28228071 | 0.71 | KMT2A (0.31) | KMT2AALDH1A1BRD4 | |
| SCHEMBL8887916 | 0.68 | KMT2A (0.35) | DNTTPOLBPOLA1KMT2AALDH1A1 | |
| SCHEMBL17322451 | 0.67 | ALDH1A1 (0.40) | DNTTPOLBPOLA1KMT2AALDH1A1 | |
| SCHEMBL2761099 | 0.67 | BRD4 (0.39) | POLBKMT2AALDH1A1BRD4 | |
| SCHEMBL10919849 | 0.60 | TDP1 (0.34) | POLBALDH1A1 | |
| SCHEMBL13911364 | 0.60 | ALDH1A1 (0.35) | DNTTPOLBPOLA1KMT2AALDH1A1 | |
| SCHEMBL3058001 | 0.60 | KMT2A (0.35) | KMT2AALDH1A1BRD4 | |
| SCHEMBL7929530 | 0.60 | DNTT (0.37) | DNTTPOLBPOLA1ALDH1A1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471010-B2 | Synthesis of dihydrothieno[3,2-d]pyrimidine diols | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| EP-2315755-B1 | SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS | BOEHRINGER INGELHEIM INT (DE) | 2012-08-08 | — | — | EP | disclosed |
| US-20110130563-A1 | SYNTHESIS IF DIHYDROTHIENO[3,2-D]PYRIMIDINE DIOLS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-02 | — | — | US | disclosed |
| EP-2315755-A2 | SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS | Boehringer Ingelheim International GmbH (DE) | 2011-05-04 | — | — | EP | disclosed |
| WO-2009140127-A2 | SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-19 | — | — | WO | disclosed |
| US-5541202-A | New leukotriene-B4 Antagonists and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCAFT (DE) | 1996-07-30 | — | — | US | disclosed |
| US-4143050-A | MANUFACTURE OF 3-HALOSULFONYLTHIOPHENE-CARBOXYLIC ACID COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 1979-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130563-A1 | SYNTHESIS IF DIHYDROTHIENO[3,2-D]PYRIMIDINE DIOLS | DPYD, DHODH, PDE4B | DNTT 144/4885POLB 457/4885POLA1 869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.