Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.38 |
| ▸ | UGT1A4 | P22310 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11113639 | 0.76 | EGLN3 (0.43) | FDPSEGLN3ALDH1A1CYP3A4LMNA | |
| SCHEMBL7813444 | 0.76 | — | — | |
| SCHEMBL11168444 | 0.72 | FDPS (0.56) | FDPSEGLN3HSP90AA1CYP19A1UGT1A4 | |
| SCHEMBL4640786 | 0.72 | FDPS (0.56) | FDPSEGLN3HSP90AA1CYP19A1UGT1A4 | |
| SCHEMBL9000195 | 0.72 | FDPS (0.51) | FDPSEGLN3HSP90AA1 | |
| SCHEMBL6984785 | 0.71 | FDPS (0.50) | FDPSEGLN3HSP90AA1CYP19A1UGT1A4 | |
| SCHEMBL9000142 | 0.70 | FDPS (0.49) | FDPSEGLN3 | |
| SCHEMBL8541749 | 0.70 | HSP90AA1 (0.36) | FDPSEGLN3HSP90AA1CYP19A1UGT1A4 | |
| SCHEMBL21277060 | 0.69 | FDPS (0.53) | FDPSEGLN3HSP90AA1CYP19A1UGT1A4 | |
| SCHEMBL10721461 | 0.68 | EGLN3 (0.47) | FDPSEGLN3HSP90AA1CYP19A1UGT1A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9486422-B2 | Small molecule inhibitors of Mcl-1 and the uses of thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-08 | — | — | US | disclosed |