Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.37 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18210777 | 0.83 | AKR1C3 (0.50) | FFAR1PPARDPDK2PTGS2AKR1C3 | |
| SCHEMBL278536 | 0.79 | SOD1 (0.50) | PDK2PPARGPPARACCR6KAT6A | |
| SCHEMBL25581911 | 0.77 | KIF11 (0.49) | AKR1C3AKR1C2KIF11ALOX5AP | |
| SCHEMBL25583367 | 0.75 | AKR1C3 (0.56) | PTGS2AKR1C3AKR1C2KIF11 | |
| SCHEMBL21571884 | 0.72 | AKR1C3 (0.56) | AKR1C3AKR1C2KIF11MAOBALOX5AP | |
| SCHEMBL12050566 | 0.71 | SCD (0.49) | PDK2AKR1C3AKR1C2KIF11 | |
| SCHEMBL21771001 | 0.70 | CCR6 (0.48) | PDK2PPARGPPARACCR6KAT6A | |
| SCHEMBL25744911 | 0.70 | SOD1 (0.48) | FFAR1PPARDPPARGPPARACCR6 | |
| SCHEMBL6123644 | 0.69 | SMN1; SMN2 (0.52) | MAOBNR4A2 | |
| SCHEMBL20347942 | 0.68 | SOD1 (0.49) | FFAR1PPARDPPARGNR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9486422-B2 | Small molecule inhibitors of Mcl-1 and the uses of thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-08 | — | — | US | disclosed |