Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | POLB | P06746 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | G6PD | P11413 | 4/20 | 0.63 |
| ▸ | BLM | P54132 | 4/20 | 0.63 |
| ▸ | CFTR | P13569 | 4/20 | 0.63 |
| ▸ | GOPC | Q9HD26 | 4/20 | 0.63 |
| ▸ | TDP2 | O95551 | 4/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 15/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 7/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.58 |
| ▸ | HKDC1 | Q2TB90 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | FABP4 | P15090 | 1/20 | 0.58 |
| ▸ | NSD2 | O96028 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14851313 | 0.92 | POLB (0.75) | MEN1POLBKMT2AG6PDBLM | |
| SCHEMBL18210665 | 0.89 | MEN1 (0.63) | MEN1POLBKMT2AG6PDBLM | |
| SCHEMBL18210698 | 0.84 | MEN1 (0.79) | MEN1POLBKMT2AG6PDBLM | |
| SCHEMBL18210694 | 0.83 | MEN1 (0.62) | MEN1POLBKMT2AG6PDBLM | |
| SCHEMBL18210736 | 0.82 | MEN1 (0.57) | MEN1POLBKMT2AG6PDBLM | |
| SCHEMBL18210669 | 0.82 | MCL1 (0.66) | MEN1POLBKMT2AG6PDBLM | |
| SCHEMBL18210676 | 0.82 | MCL1 (0.62) | MEN1POLBKMT2AG6PDBLM | |
| SCHEMBL14851306 | 0.81 | MEN1 (0.75) | MEN1POLBKMT2AG6PDBLM | |
| SCHEMBL18210675 | 0.81 | HKDC1 (0.67) | MEN1POLBKMT2AG6PDBLM | |
| SCHEMBL18210671 | 0.81 | MCL1 (0.82) | MEN1POLBKMT2AG6PDBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9486422-B2 | Small molecule inhibitors of Mcl-1 and the uses of thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-08 | — | — | US | disclosed |