Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 1/20 | 0.32 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 4/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | PIR | O00625 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.30 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.30 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.30 |
| ▸ | STK16 | O75716 | 1/20 | 0.30 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24594035 | 0.85 | MAP2K1 (0.39) | BRD4PDPK1JAK2PLK4ABL1 | |
| SCHEMBL3821880 | 0.82 | CYP2C9 (0.42) | BRD4LCKCSF1RPDGFRBKIT | |
| SCHEMBL19829825 | 0.82 | BRD4 (0.40) | BRD4S1PR3JAK2TRPA1LCK | |
| SCHEMBL18211756 | 0.82 | MAP3K11 (0.47) | BRD4JAK2MAP3K11BRAFBMPR1B | |
| SCHEMBL19287905 | 0.80 | BRD4 (0.43) | BRD4JAK2MAP3K11BRAFLCK | |
| SCHEMBL858686 | 0.79 | BRD4 (0.34) | BRD4 | |
| SCHEMBL12675104 | 0.77 | SYK (0.31) | PDPK1SYK | |
| SCHEMBL15472398 | 0.76 | SYK (0.31) | SYK | |
| SCHEMBL858112 | 0.75 | LMNA (0.39) | MAP2K1HIPK2CYP2C9CYP2C19 | |
| SCHEMBL858347 | 0.75 | PIK3CA (0.39) | BRD4PDPK1SGK1KITCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3581573-B1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | PLEXXIKON INC (US) | 2022-07-06 | — | — | EP | disclosed |
| US-10730876-B2 | Synthesis of a compound that modulates kinases | PLEXXIKON INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20190337943-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | DAIICHI SANKYO, INC. | 2019-11-07 | — | — | US | disclosed |
| US-10399975-B2 | Synthesis of a compound that modulates kinases | PLEXXIKON INC. (US) | 2019-09-03 | — | — | US | disclosed |
| US-10040792-B2 | Synthesis of a compound that modulates kinases | PLEXXIKON INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-10040792-B2 | Synthesis of a compound that modulates kinases | PLEXXIKON INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-20170334909-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | DAIICHI SANKYO, INC. | 2017-11-23 | — | — | US | disclosed |
| US-20170334909-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | DAIICHI SANKYO, INC. | 2017-11-23 | — | — | US | disclosed |
| US-9802932-B2 | Solid forms of a compound modulating kinases | PLEXXIKON INC. (US) | 2017-10-31 | — | — | US | disclosed |
| US-9802932-B2 | Solid forms of a compound modulating kinases | PLEXXIKON INC. (US) | 2017-10-31 | — | — | US | disclosed |
| US-9745298-B2 | Synthesis of a compound that modulates kinases | PLEXXIKON INC. (US) | 2017-08-29 | — | — | US | disclosed |
| US-9745298-B2 | Synthesis of a compound that modulates kinases | PLEXXIKON INC. (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160326169-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | DAIICHI SANKYO, INC. | 2016-11-10 | — | — | US | disclosed |
| US-20160326169-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | DAIICHI SANKYO, INC. | 2016-11-10 | — | — | US | disclosed |
| WO-2016179412-A1 | SYNTHESIS OF 1 H-PYRROLO[2,3-B]PYRIDIN DERIVATIVES THAT MODULATE KINASES | PLEXXIKON INC. (US) | 2016-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730876-B2 | Synthesis of a compound that modulates kinases | FLT3, KIT, MAP3K1 | BRD4 1088/4885S1PR3 1296/4885PDPK1 135/4885 |
| US-20190337943-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | FLT3, KIT, MAP3K1 | BRD4 1088/4885S1PR3 1296/4885PDPK1 135/4885 |
| US-10399975-B2 | Synthesis of a compound that modulates kinases | FLT3, KIT, MAP3K1 | BRD4 1088/4885S1PR3 1296/4885PDPK1 135/4885 |
| US-10040792-B2 | Synthesis of a compound that modulates kinases | FLT3, KIT, MAP3K1 | BRD4 1088/4885S1PR3 1296/4885PDPK1 135/4885 |
| US-20170334909-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | FLT3, KIT, MAP3K1 | BRD4 1088/4885S1PR3 1296/4885PDPK1 135/4885 |
| US-20160326169-A1 | SYNTHESIS OF A COMPOUND THAT MODULATES KINASES | FLT3, KIT, MAP3K1 | BRD4 1088/4885S1PR3 1296/4885PDPK1 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.