Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 4/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823517 | 0.83 | MAPT (0.40) | PPARGPPARAL3MBTL1SMN1; SMN2POLB | |
| SCHEMBL1822482 | 0.81 | BCHE (0.41) | SMN1; SMN2POLBKDM4E | |
| SCHEMBL1820650 | 0.79 | PLA2G1B (0.42) | PPARGPPARASMN1; SMN2 | |
| SCHEMBL1824801 | 0.79 | MCL1 (0.43) | L3MBTL1SMN1; SMN2 | |
| SCHEMBL1820465 | 0.78 | KMT2A (0.38) | TDP1SMN1; SMN2POLBKDM4E | |
| SCHEMBL1820820 | 0.77 | POLB (0.38) | PPARGPPARAMAPK1L3MBTL1TSHR | |
| SCHEMBL1821326 | 0.72 | PPARG (0.45) | PPARGPPARAMAPK1L3MBTL1TSHR | |
| SCHEMBL1819393 | 0.69 | PARP1 (0.44) | MAPK1TSHRSMN1; SMN2POLBKDM4E | |
| SCHEMBL23666618 | 0.69 | KDM4E (0.43) | PPARGPPARAMAPK1L3MBTL1TSHR | |
| SCHEMBL1819713 | 0.69 | MAOB (0.42) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947712-B2 | Antiarthritic agents; asthma; chronic obstructive pulminary diosrders; atherosclerosis; vision defects; hepatitis; central nervous system disorders; cardiovascular disorders; wound healing agents; restenosis; cirrhosis; multiple sclerosis; glomerulonephritis; graft versus host disease; antidiabetic agent | WYETH LLC (US) | 2011-05-24 | — | — | US | disclosed |